4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency

J Med Chem. 1995 Aug 18;38(17):3189-92. doi: 10.1021/jm00017a001.

Authors

R K Bakshi¹, G H Rasmusson, G F Patel, R T Mosley, B Chang, K Ellsworth, G S Harris, R L Tolman

Affiliation

¹ Department of Medicinal Chemical Research, Molecular Systems, and Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA.

PMID: 7650670
DOI: 10.1021/jm00017a001

No abstract available

MeSH terms

5-alpha Reductase Inhibitors*
Androstenes / chemistry
Androstenes / pharmacology*
Azasteroids / chemistry
Azasteroids / pharmacology*
Humans
Molecular Conformation
Thermodynamics

Substances

5-alpha Reductase Inhibitors
Androstenes
Azasteroids